Hakkasin neljännesvuosisadan (1965-90) päätäni seinään talousveden fluorauskysymyksessä. Vastustus oli raudanluja. Sen seurauksena hammaskaries on edelleen suurimpia kansantautejamme ja koko lääkärikunnasta joka viides on hammaslääkäri. Nyt huudetaan hammaslääkäripulaa ja avataan taas hammaslääketieteen laitos toisensa jälkeen - ja mikäpä siinä, kun maamme on rikas kuin Kroisos.
Oli kuitenkin mielenkiintoista saada tänään 23.12.2008 Yhdysvaltain kansanterveysjärjestön perusteltu julkilausuma talousveden fluoripitoisuuden optimoinnista terveydelle parhaalle tasolle.
Water Fluoridation in USA;
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Community Water Fluoridation in the United States
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Community Water Fluoridation in the United States
This position paper provides updated evidence for the many supportive policies held by the American Public Health Association (APHA) on community water fluoridation (CWF). This position paper provides the scientific basis and justification for the importance of continuing to support CWF for our nation’s public water supplies. It also emphasizes the critical role that public health practitioners, health care professionals, and policymakers can play with respect to this important public health practice. The position paper will enable APHA to continue as a policy leader for CWF and safe drinking water. The objectives of this position paper are for APHA to be well positioned to—
• Provide expert guidance to regulatory agencies on decision-making regarding CWF standards and regulations;
• Improve public health education about the safety and efficacy of CWF, specifically education for public health and other health professionals, decision makers, and the public; and
• Promote sufficient funding for federal, state, and local CWF programs.
Relationship to Existing APHA Policies
The following APHA policies are updated and replaced by this position paper and are archived with the adoption of this resolution: 5005, 5508, 5904, 6912, and 7402.
Tooth decay (dental caries) is one of the most common diseases in our country, affecting almost the total population. Although the scientific evidence base supports CWF as the foundation for improving a community’s public health by minimizing the prevalence and severity of tooth decay, many communities have not successfully initiated or continued this public health measure.1–4 Those opposed to fluoridation sow doubts about the risks and benefits of CWF, often with little scientific basis. In addition, there is often insufficient advocacy for CWF in the face of ongoing media campaigns by activists opposed to fluoridation, commonly referred to in the literature as antifluoridationists.2
Support for CWF
Since 1950,5 APHA has supported CWF as a safe and effective public health measure for the prevention of dental caries (tooth decay), reaffirming this policy in 1955,6 1956,7 1959,8 1963,9 1965,10 1969,11 1974,12 1975,13 1976,14 1977,15,16 1979,17 1980,18 1982,19,20 1992,21 1997,22 2000,23 2001,24 and 2006.25 In addition, more than 100 national and international organizations have recognized the public health benefits of community water fluoridation.26
Because of its health and economic benefits, CWF has been and is included in the 1990, 2000, and 2010 national health objectives (e.g., Healthy People 2010). Between 1992 and 2002, the proportion of the US population served by CWF increased from 62% to 67%. The Healthy People 2010 CWF objective [21–9] is to increase to 75% the proportion of the US population served by community water systems with optimally fluoridated water.27
More Americans have access to fluoridated drinking water than ever before; in 2006, it was estimated that 184 million or 69% of those served by public water supplies and 61.5% of the US population overall had access to optimally fluoridated water.28 More than 405 million people in more than 60 countries worldwide enjoy the benefits of fluoridated water.29 Community water fluoridation has been hailed as one of 10 great public health achievements of the 20th century.30
Because many communities have not yet adopted fluoridation, the US Centers for Disease Control and Prevention (CDC) has set as a priority the evaluation of the effectiveness of laws, policies, and incentives related to water fluoridation and other public health measures designed to promote and sustain health for all residents across diverse community settings.31 However, opposition to this well-supported public health program continues to frustrate efforts by communities to begin or to continue fluoridation.2
Safety of CWF
The scientific evidence base continues to support CWF as a safe and effective public health measure. Reviews of the scientific literature on the health effects of fluoride in the last 18 years have been conducted by the National Health and Medical Research Council, Australian Government (2007)32; National Research Council (NRC), USA (1993, 2006)33,34; World Health Organization (1994, 1996, 2006)35–37; US Agency for Toxic Substances and Disease Registry (2003)38; International Programme on Chemical Safety; WHO (2002)39; Forum on Fluoridation, Ireland (2002)40; Medical Research Council, UK (2002)41; University of York, UK (2000)42,43; Institute of Medicine, USA (1999)44; Health Canada (1999)45; Lewis and Banting, Canada (1994)46; US Public Health Service (1991)47; and Kaminsky et al., New York State Department of Health (1990).48 In addition, the environmental impact of CWF has been reviewed.49,50 All of these reviews have found CWF to be safe and effective. Opponents have claimed potential toxicity from fluoridated water, but none of these claims has been supported by studies of scientific merit.2,51
Water safety is defined and determined by federal, state, and local regulations. The main federal law that ensures the quality of US drinking water is the Safe Drinking Water Act (SDWA). Under SDWA, the US Environmental Protection Agency (EPA) sets standards for drinking water quality and oversees the states, localities, and water suppliers who implement those standards. The current maximum contaminant level goal (MCLG) for fluoride in water is set at 4.0 mg/L,52 well above the optimal levels (0.7 mg/L F–1.2 mg/L F) currently recommended for CWF in the United States for the prevention of tooth decay.53 It has recently been recommended by a committee of the NRC that the MCLG of 4 mg/L for naturally occurring fluoride in water should be lowered to protect against the development of severe enamel fluorosis. The majority of the NRC committee concluded that the MCLG of 4 mg/L is not likely to be protective against bone fractures. Although the NRC committee concluded that the secondary maximum contaminant level of 2 mg/L adequately protects the public from the most severe stage of enamel fluorosis (enamel pitting), there were few studies to assess bone fracture risk in populations exposed to fluoride at the same level in drinking water. However, there was evidence that none of these concerns exist at the optimal levels of fluoride for the prevention of tooth decay.34
Fluorosilicic acid (FSA) is commonly used to fluoridate water. The majority of FSA samples have no impurities, and there is no credible evidence that the use of FSA is of concern.49,54,55
Legality of CWF
During the last 60 years, the legality of fluoridation in the United States has been thoroughly tested in our court systems.56 Fluoridation is viewed by the courts as a proper means of furthering public health and welfare.57 No court of last resort has ever rendered an opinion against fluoridation. The highest courts of more than a dozen states have confirmed the constitutionality of fluoridation.58 In 1984, the Illinois Supreme Court upheld the constitutionality of the state’s mandatory fluoridation law, culminating 16 years of court action at a variety of judicial levels.59 Moreover, the US Supreme Court has denied review of fluoridation cases 13 times, citing that no substantial federal or constitutional questions were involved.58
It has been the position of the US courts that a significant government interest in the health and welfare of the public generally overrides individual objections to public health regulation.1 Consequently, the courts have rejected the contention that fluoridation ordinances are a deprivation of religious or individual freedoms guaranteed under the Constitution.58,60 In reviewing the legal aspects of fluoridation, the courts have dealt with this concern by ruling that (1) fluoride is a nutrient, not a medication, and is present naturally in the environment; (2) no one is forced to drink fluoridated water because alternative sources are available; and (3) when a person believes that fluoridation interferes with religious beliefs, there is a difference between the freedom to believe, which is absolute, and the freedom to practice beliefs, which may be restricted in the public’s interest.61,62 Courts have consistently ruled that water fluoridation is not a form of compulsory mass medication or socialized medicine.58,61 Recent legal decisions have upheld CWF, including the use of FSA, that there is no fundamental constitutional right to fluoride-free water, and that the use of fluoride is not forced medication.63–66
Continued Benefit and Need for Fluoridation
There is a continued need for CWF to maintain and enhance the reduced prevalence and severity of dental caries. Dental caries remains the most prevalent chronic disease of childhood, with 28% of children aged 2 to 5 years affected by tooth decay. The incidence of dental caries is experienced by 6 of 10 adolescents (12–19 years) and more than 90% of adults (20–64 years).67 The prevalence and severity of dental caries has decreased significantly in the United States as a result of CWF and the nearly ubiquitous use of fluoride toothpaste. The US Task Force on Community Preventive Services strongly recommended CWF for the prevention of dental caries.68 The review that included 21 studies, considered good to fair quality, found a median decrease in dental caries of 29.1% (before-and-after measures) and 50.7% (after measures only) for children aged 4 to 17 years, with varying levels of baseline caries and socioeconomic status. The task force found the evidence of effectiveness was strong. Overall, the prevalence of dental caries among children aged 12 to 17 years declined from 90% in 1971 to 1974 to 67% in 1988 to 1991, and the mean number of teeth that were decayed, missing, or filled (DMFT) as a result of caries declined from 6.2 to 2.8 during this period. More recent data have been aggregated into different age groups of adolescents; for 12 to 19 year olds, the mean DMFT declined from 3.1 in 1988 to 1994 to 2.55 in 1999 to 2004. For 20 to 64 year-old adults, there continues to be a decline in the number of DMFT, from a mean of 12.5 in 1988 to 1994 to 10.3 in 1999 to 2004.67
There is a benefit from the diffusion of fluoride from fluoridated communities to surrounding nonfluoridated communities via the export of bottled beverages and processed foods.69 This diffusion effect, also referred to as the halo effect, as well as additional sources of fluoride, have reduced the absolute and proportional benefit of water fluoridation, as measured between fluoridated and nonfluoridated communities, from approximately 60% in the 1950 to 1970 era to 18% to 40% since the 1980s. Based on 1986 to 1987 data,70 in regions where 75% of public water supplies are fluoridated, the benefit may not be apparent when measuring caries experience between fluoridated and nonfluoridated communities because of the halo or diffusion effect.71 However, in the Pacific region of the United States where less than 20% of public water supplies were fluoridated, there was a 60% difference in tooth decay experience between fluoridated and non-fluoridated communities.71 Continued CWF programs are essential to maintaining this improved oral health status.
Benefit for Adults
CWF benefits everyone in the community, including adults and seniors as well as children. The combined results of 9 studies (7853 participants) examining the effectiveness of water fluoridation in preventing tooth decay in adults were found to be significant at p < .001.72 Adults have more tooth and root surfaces at risk for tooth decay than children. The incidence of dental caries for adults equals or exceeds that of children.73,74 Griffin et al. summarized the need for placing increased attention on the prevention of tooth decay in adults72:
Although adults are as likely to experience new caries as children, certain segments of the US adult population—those with low incomes and the elderly—may have little or no access to restorative or preventive clinical care. At present, approximately 15% of state Medicaid programs provide no adult dental benefits at all, and approximately 45% cover only tooth extraction and emergency services (Oral Health America, 2003). Routine dental care is one of the few health areas not covered by Medicare. Limited access to restorative care increases the need for effective prevention; complications and pain and suffering are more likely if caries remain untreated. The proportion of the US population comprised of older adults is increasing, most of these persons are likely to be dentate and at risk for dental caries, and many lower-income adults lack access to timely restorative care. Our finding that fluoride is effective among all adults supports the development and implementation of fluoride programs to serve this population.72, p 414-5
Fluoridation is a highly cost-effective means of preventing tooth decay in the United States, regardless of socioeconomic status.75–77 The cost of CWF can vary in each community depending on several factors: size of the community (population and water usage); number of fluoride injection points where fluoride will be added to the water system; amount and type of equipment used to add and monitor fluoride levels; amount and type of fluoride compound used, its price, and its costs of transportation and storage; and expertise of personnel at the water plant.78 The annual cost for a US community to fluoridate its water is estimated to range from approximately $3.00 per person in small communities to approximately $0.50 per person in large communities.76
Cost Savings of CWF
For communities of more than 20,000 people where it costs approximately $0.50 per person per year to fluoridate the water, every $1.00 (1995) invested in this preventive measure yields approximately $38 savings in dental treatment costs.79 At least 60% of the US population on public water systems has received fluoridated water since 1990, translating to savings in dental treatment costs of more than $25.7 billion between 1990 and 2000.80
In analyzing annual per person cost savings resulting from fluoridation, Griffin, Jones, and Tomar found a range from $16 in very small communities to $19 in large communities.76 These authors concluded, “On the basis of the most current data available on the effectiveness and cost of fluoridation, caries increment, and the cost and longevity of dental restorations, we find that water fluoridation offers significant cost savings.”76, p78
The annual incremental mean benefit of fluoridation has been found to be 0.19 tooth surfaces (range 0.04 to 0.34). This equates to a mean of 1.9 tooth surfaces every decade, or 9.5 tooth surfaces over 50 years.76 Preventing 10 tooth surfaces from decay translates into preventing the need for 10 fillings or perhaps two molars from needing crowns (a molar has five tooth surfaces). The tooth surface index (DMFS) does not address the severity of decay in any one surface or the need for treatment, which could vary from a small filling to a root canal treatment and crown or an extraction.
Because of the multifactorial nature of tooth decay, oral health disparities within and between countries are related to sugar consumption, fluoride use, dental care, and social determinants of health.80 However, it has been shown that children with the greatest dental need and who are at highest risk for tooth decay benefit the most from water fluoridation.82–87 Therefore, CWF helps reduce disparities in tooth decay prevalence. This has been most eloquently and succinctly articulated by Burt: “There is no practical alternative to water fluoridation for reducing these disparities in the United States.”88, p195
Pre- and Post-Eruptive Benefits
Fluoridation protects teeth in two ways: systemically, when delivered through the water supply to children during the tooth forming years, and topically, through direct contact with teeth throughout life.89 Animal and human studies have demonstrated the topical and systemic benefits of fluoride.90,91 Epidemiological studies using data collected between 1991 and 1995 on children in Australia have confirmed earlier findings that higher pre- than posteruptive fluoride exposure is more beneficial for overall caries experience and for pit and fissure surfaces caries reduction. In those studies, children with optimum exposure to fluoridated water both pre- and posteruption had the lowest caries levels in all surface types and there was an exposure–response relationship between preeruptive exposure and caries.92–94
Total Fluoride Intake and Enamel Fluorosis
Enamel fluorosis is a biomarker of fluoride intake during tooth developing years. In a minority of children, fluoride exposure from birth through age 8, when teeth are forming, may result in changes within the outer surface of the tooth called enamel fluorosis. Fluorosis occurs only on primary and permanent teeth while they are forming under the gums; once the teeth come into the mouth, they are no longer able to develop this condition. Clinically, the appearance of enamel fluorosis may vary and is usually bilateral. In its mildest form, it appears as faint white lines or streaks visible only to trained examiners under controlled examination conditions. In its pronounced moderate form, fluorosis manifests as white mottling of the teeth in which noticeable white lines or streaks often have coalesced into larger opaque areas; brown staining of the enamel also may be present. In its most severe form, pitting and actual breakdown of the enamel may occur. The prevalence of severe enamel fluorosis is very low (near zero) at fluoride concentrations in drinking water less than 2 mg/L.95 In recent years, there has been an increase in the prevalence of children seen with nonsevere enamel fluorosis in both optimally fluoridated and nonfluoridated areas of the United States. The greatest relative increase in enamel fluorosis prevalence has occurred in nonfluoridated areas.96 Although US NHANES data from 1999–2002 have shown that 32% of US children aged 6 to 19 years have some enamel fluorosis,97 few survey participants had severe enamel fluorosis and less than 4% had moderate or severe enamel fluorosis. Although professional interest in limiting the amount of fluoride toothpaste delivered to young children and supervising their toothbrushing was expressed in the 1980s as a means of reducing the risk for enamel fluorosis, only during the early 1990s was this approach adopted broadly as a public health measure, which was too late to alter the risk for fluorosis among the 12 to 19 year age cohort in NHANES 1999–2002.97 Although it has been estimated that only approximately 2% of US schoolchildren may experience perceived esthetic problems related to enamel fluorosis that could be attributed to the currently recommended levels of fluoride in drinking water,98 in more recent studies, it has been found that mild fluorosis does not have a negative association on the perception of dental appearance.99 Children and their parents who had mild fluorosis were even better off in perception of oral health when other factors were controlled for in multivariate models. This rather unexpected finding, the authors suggest, might be explained by the fact that better oral health was often perceived as being without caries.99
Various studies in Canada, Australia, and the United States have shown a relationship between young children swallowing too much fluoride from fluoride toothpaste and subsequent enamel fluorosis development.96,100,101 In a study of 10- to 14-year-old children in Massachusetts and Connecticut, Pendrys found that enamel fluorosis in the optimally fluoridated study sample was attributed to early toothbrushing behaviors, inappropriate fluoride supplementation, and the use of infant formula in the form of a powdered concentrate.96 Enamel fluorosis in the nonfluoridated study sample was attributed to fluoride supplementation under the pre-1994 protocol and early toothbrushing behaviors. In the nonfluoridated study sample, 65% of the enamel fluorosis cases were attributed to fluoride supplementation under the pre-1994 protocol. An additional 34% was explained by the children swallowing fluoride toothpaste when they brushed more than once per day during the first 2 years of life. In the optimally fluoridated study sample, 68% of the enamel fluorosis cases were explained by the children using more than a pea-sized amount of toothpaste during the first year of life, 13% by having been inappropriately given a fluoride supplement, and 9% by the use of infant formula in the form of a powdered concentrate. Recommendations have been made to reduce the occurrence of enamel fluorosis by controlling identified risk factors.78
Fluoride Intake From Foods and Beverages
Water and water-based beverages are the chief source of dietary fluoride intake. Conventional estimates are that approximately 65% to 75% of dietary fluoride comes from water and water-based beverages.102 In 1997, the Food and Nutrition Board of the Institute of Medicine developed a comprehensive set of reference values for dietary nutrient intakes.44 The adequate intake (AI) establishes a goal for intake to sustain a desired indicator of health without causing side effects. In the case of fluoride, the AI is the daily intake level required to reduce dental decay without causing moderate enamel fluorosis. The AI for fluoride from all sources (fluoridated water, food, beverages, fluoride-containing dental products and dietary fluoride supplements) is set at 0.05 mg/kg/day.44 Using the established AI of 0.05 mg/kg, the amount of fluoride for optimal health to be consumed each day has been calculated by gender and age group (expressed as average weight).103 The tolerable upper intake levels (UL) are higher than the AI and are not the recommended level of intake. The UL is the estimated maximum intake level that should not produce unwanted effects on health. The UL for fluoride from all sources (fluoridated water, food, beverages, fluoride-containing dental products and dietary fluoride supplements) is set at 0.10 mg/kg/day for infants, toddlers, and children through 8 years of age. For older children and adults, who are no longer at risk for enamel fluorosis, the UL for fluoride is set at 10 mg/day, regardless of weight.44
Dietary fluoride intakes by adults from food, water, and beverages, where the concentration is 1.0 parts per million (ppm) fluoride in water, range from 1.4 to 3.4 mg/day; where the concentration is less than 0.3 ppm fluoride, the range is from 0.3 to 1.0 mg/day.44 USEPA has set the MCLG for fluoride in drinking water at 4 mg/L; by converting the MCLG of 4.0 mg/L to a mg/kg/day basis using standard water consumption estimates and body weight data from the NHANES III survey, EPA has concluded that dietary exposure to fluoride, including food exposure to sulfuryl fluoride used as an insecticide, uses 35% of the MCLG (expressed as mg/kg/day) for the US population; 23% of the MCLG (expressed as mg/kg/day) for youth 13 to 19 years, 37% of the MCLG (expressed as mg/kg/day) for children 3 to 5 years, 28% of the MCLG (as mg/kg/day) for children 1 to 2 years, and 35% of the MCLG (expressed as mg/kg/day) for all infants younger than 1 year old. These risk estimates are below the USEPA’s level of concern.104
Infant Formula and the Risk for Enamel Fluorosis
Although only a small factor in the risk for enamel fluorosis, the American Dental Association (ADA) (and the CDC) has issued guidance for parents and caregivers of infants younger than 12 months of age to consult with their pediatrician, family physician, or dentist on the most appropriate type of water to use to reconstitute infant formula.105 Recent evidence suggests that mixing powdered or liquid infant formula concentrate with fluoridated water on a regular basis for infants primarily fed in this way may increase the chance of a child’s developing the faint white markings of very mild or mild enamel fluorosis. Occasional use of water containing optimal levels of fluoride should not appreciably increase a child’s risk for fluorosis. Studies have not shown that teeth are likely to develop more esthetically noticeable forms of fluorosis, even with regular mixing of formula with fluoridated water.106
CWF and Fluoride Toothpaste
Because frequent exposure to small amounts of fluoride each day will best reduce the risk for dental caries in all age groups, all people are recommended to drink water with an optimal fluoride concentration and to brush their teeth twice daily with fluoride toothpaste.78 Fluoride is the only nonprescription toothpaste additive proven to prevent dental caries.78 Because water fluoridation is not available in many countries, toothpaste might be the most important source of fluoride globally.78 There is an additive benefit of fluoride toothpaste. Combined use of fluoride toothpaste and fluoridated water offers protection greater than either used alone.78 In the United States, the standard concentration of fluoride in fluoride toothpaste is 1,000 to 1,100 ppm. Fluoride toothpaste is helpful to all age groups and should be used at least twice a day. Since 1991, manufacturers of fluoride toothpaste marketed in the United States have, as a requirement for obtaining the ADA Seal of Acceptance, placed instructions on the package label stating that children aged younger than 6 years should use only a pea-sized amount of fluoride toothpaste. This is reported to sharply reduce the role of fluoride toothpaste as a risk factor for enamel fluorosis.107 Toothpaste labeling requirements mandated by FDA in 1996 also direct parents of children aged younger than 2 years to seek advice from a dentist or physician before introducing their child to fluoride toothpaste.108 Children younger than 6 years of age should have parents supervise and apply the toothpaste so as to limit the amount that may be swallowed; fluoride toothpaste should be spit out rather than swallowed.
The propensity of young children to swallow toothpaste has led to development of “child-strength” toothpaste with lower fluoride concentrations. Such a product, not currently available in the United States, would be a desirable alternative to currently available products for many young children. Toothpaste containing 500 to 550 ppm fluoride might be almost as efficacious as that containing 1,000 ppm fluoride.109 A British study reported that the prevalence of diffuse enamel opacities (an indicator of mild enamel fluorosis) in the upper incisors was substantially lower among children who used toothpaste containing 550 ppm fluoride than among those who used toothpaste containing 1,050 ppm fluoride.110 An Australian study reported a decrease in the prevalence of enamel fluorosis and no increase in caries after steps were taken to promote use of toothpaste for children containing 400 ppm fluoride and reduce dosages for dietary supplements.111
Adults benefit considerably from CWF and fluoride toothpaste. A review of adult studies after 1980 found that any fluoride, whether self-applied, professionally applied, via water fluoridation, or in combination, averted 0.51 carious coronal and root surfaces per year.72
Fluoridation and Dental Sealants
The effectiveness of dental sealants in community-based programs may be further improved when coupled with lifetime exposure to optimally fluoridated water.112
In 2006, the FDA’s Center for Food Safety and Applied Nutrition issued a Health Claim Notification for Fluoridated Water and Reduced Risk of Dental Caries.113 Labels on bottled water with 0.6 to 1.0 mg/L fluoride may claim “Drinking fluoridated water may reduce the risk of [dental caries or tooth decay].” In addition, the health claim is not intended for use on bottled water products specifically marketed for use by infants.
Because the use of bottled water has increased and because the majority of commercial bottled water is low in fluoride, there is the potential for an increase in dental caries.114,115 To encourage bottled water manufacturers to provide optimally fluoridated water, the ADA has introduced a certification program for foods and beverages that are beneficial to oral health, including fluoridated bottled water.116
Per capita consumption of bottled water has increased from approximately 190 mL/person/day in 2001 to approximately 285 mL/person/day in 2006.117 Considering water from all sources, EPA surveys in 1994 to 1998 found the mean per capita daily average total water ingestion was 1.233 L.118 In the EPA surveys, 75% was from community water, 13% from bottled water, 10% from other sources (e.g., well, spring, and cistern), and 2% from unidentified sources. Assuming no general increase in overall water consumption, bottled water use has increased from 15% in 2001 to 23% in 2006 as a proportion of total water consumption. ADA recommends that dentists ask their patients about bottled water use and advise them about the possible removal of fluoride by some home water treatment systems.118 Further, ADA and CDC recommend labeling of bottled water with the fluoride concentration of the product.78,119
Salt fluoridation is practiced as a community-based alternative to water fluoridation in many countries where there are few central water systems, water infrastructure is otherwise not appropriate, or where other factors preclude the use of water fluoridation. It has been estimated that 40 million people use salt fluoridation, mainly in European, South American, and Central American countries.120 A concentration of 200 to 250 mg fluoride per kg salt is typically used in fluoridated salt. It is recommended that a national fluoride program use only one of these approaches.121
Where community water fluoridation is not feasible because there is no central water supply or because there are a large number of wells and a small population, school-based fluoride supplement programs are an alternative for communities with suboptimal fluoride in drinking water.122 Prescription fluoride supplements (of 0.25 mg/day, 0.5 mg/day, or 1 mg/day, depending on the age of the child and the concentration of fluoride in the water supply—whether less than 0.3 mg/L or between 0.3 and 0.6 mg/L, and all sources of fluoride) are currently recommended daily for children between 6 months of age and 16 years where the fluoride concentration of the water supply is less than 0.6 mg/L (ppm).78 Currently, in addition to age and fluoride concentration of drinking water, all sources of fluoride should be evaluated with a thorough fluoride history when physicians or dentists prescribe fluoride supplements. Patient exposure to multiple water sources can make proper prescribing complex.123
Home compliance with use of fluoride supplements can be challenging. Health care providers must educate parents, or school personnel in the case of school-based programs, about the appropriate use of the fluoride supplements; moreover, parents and recipients must understand the importance of fluoride supplements, the recommended dose, and the need for compliance on a daily basis for many years. Concomitantly, fluoride supplements are not always prescribed as recommended; studies have found more than one third of children receive prescriptions with incorrect dosage or do not receive prescriptions.124,125 Long-term compliance with daily fluoride supplements has been reported as poor.126,127 As a public health measure, because of poor compliance by individual providers and patients in the private sector, fluoride supplements are less effective than water fluoridation for providing caries prevention. Because inappropriate prescribing of fluoride supplements in fluoridated communities and high doses of fluoride supplements have been found to contribute to enamel fluorosis, alternative doses and schedules have been proposed and are being used in other countries.128
Comparative Costs of Community-Based Tooth Decay Prevention Programs
The costs of school-based fluoride supplement programs have been compared with the cost of CWF, noting that school-based programs affect children only, whereas CWF benefits all age groups of children and adults. The cost to achieve the same level of benefit of prevention of tooth decay was three times higher for fluoride supplements provided in a school-based program compared with water fluoridation for all residents.129 The largest US study conducted to determine the cost and effectiveness of various tooth decay prevention strategies for schoolchildren was conducted between 1977 and 1982. The National Preventive Dentistry Demonstration Program found that dental health lessons, brushing and flossing, fluoride tablets and mouthrinsing, and professionally applied topical fluorides were not effective in reducing a substantial amount of dental decay, even when all of these procedures were used together. Occlusal sealants prevented 1 to 2 carious surfaces in 4 years. Children who were especially susceptible to decay did not benefit appreciably more from any of the preventive measures than did children in general. However, CWF was reaffirmed as the most cost-effective means of reducing tooth decay in children. By contrast to the $23 per year cost of maintaining a child in a sealant program, the annual per capita cost (in 1981 dollars) of water fluoridation in 5 US communities ranged from $0.06 in Denver, Colorado, to $0.80 in rural West Virginia.73
Because of the adoption of water fluoridation and widespread use of fluoride toothpaste, approximately 75% of the US public is at low risk for dental caries. Therefore, the use of any professionally applied fluoride, including fluoride varnish, should be limited to those individuals and communities deemed to be at moderate to high risk for developing dental caries.130 A targeted approach offers additional opportunities toward improving the prevention and control of dental caries.130 The use of fluoride varnish to prevent and control dental caries in young children and seniors is expanding in both public and private dental practice settings and in nondental settings that incorporate health risk assessments and counseling. These settings include Head Start programs and Special Supplemental Nutrition Programs for Women, Infants, and Children; medical offices; well-child clinics and home visits conducted by public health nurses; child care programs; and other, sometimes overlapping, community programs.
Public Information on CWF
Public opinion polls have consistently shown 70% or more of the adult US population supports fluoridation.131 Several organizations provide detailed information on CWF on Web sites, including the CDC132 and ADA.133 The ADA periodically updates Fluoridation Facts, a review of fluoridation literature in question and answer format.134 In addition, ADA has a resource list of materials.135 However, a review of Web sites providing information on CWF revealed that, of 59 sites meeting specific criteria from a list of the first 100 Web sites found when searching “water fluoridation” using the Google search engine (www.google.com) on February 15, 2003, 54% recommend water fluoridation compared with 31% that oppose it.136 Armfield analyzed Web information on fluoridation from Australia in 2006 using 5 search engines—Google, Yahoo, MSN, AOL, and Ask—and found that of the first 20 results from each Web site, searching for “water fluoridation,” 29 of the sites were for fluoridation, 55 were against it, with 9 reviews and 7 others.2 Armfield stated, “Although the overwhelming majority of scientific enquiry supports the benefits of water fluoridation, members of the public who type the term ‘water fluoridation’ into any of the major search engines would immediately be presented with a disproportionate percentage of anti-fluoridation websites.”2, p3 Thus, there may be an increasing number of Web sites providing information that is in opposition to established public health policy on water fluoridation.
Water fluoridation opponents are said to use multiple techniques to undermine the scientifically established effectiveness and safety of water fluoridation. The materials they use are often based on Internet resources or published books that present a highly misleading picture of water fluoridation. Despite an extensive body of literature, both studies and results within studies are often selectively reported, giving a biased portrayal of water fluoridation effectiveness. Positive findings are downplayed or trivialized, and the population implications of these findings misinterpreted. Ecological comparisons are sometimes used to support spurious conclusions. Opponents of water fluoridation frequently repeat that water fluoridation is associated with adverse health effects and studies are selectively picked from the extensive literature to convey only claimed adverse findings related to water fluoridation.2
Ethics of CWF
Several reviews have considered the ethics of CWF.137–140 The reviews rely on the preponderance of scientific evidence of benefit and lack of harm and have concluded that CWF is ethical, in part, because it leads to the reduction of health inequalities and the reduction of ill health, particularly among vulnerable groups, and provides an economic benefit to both society and to individuals. With water fluoridation, a whole area either receives fluoridated water or does not. Populations do not remain static, as people move to and from an area. In practical terms, it would therefore not be feasible to seek individual consent. The most appropriate way of deciding whether fluoride should be added to water supplies is to rely on democratic decisionmaking procedures, with public input informing those empowered by the public to make such public health decisions (e.g., local health board, city council, water board, or state legislature). These procedures should be implemented at the local and regional, rather than national, levels because the need for and perception of water fluoridation varies in different areas.138 Account should be taken of relevant evidence and of alternative ways of achieving the intended benefit in the area concerned. Whatever policy is adopted, dental health and any adverse effects of fluoridation should be monitored. The Nuffield Council found there is a need for better and more balanced information for the public and policymakers.138
From an ethical perspective, fluoridating water supplies can be seen as replicating the benefits already conferred on those communities receiving water naturally containing 1 part per million of fluoride. Moreover, the greatest benefit of all goes to that section of the population least able to help themselves—children. Drinking fluoride-free water is not a basic human right but a question of individual preference. In a society where people come together for mutual benefit, it is a question of balancing such personal preferences against the common good arising from less disease, less pain, less suffering, and better health that fluoridation brings.139
Dental caries (tooth decay) continues to be the most common chronic disease of childhood, and dental caries incidence for adults exceeds that of children. Although there are gross oral health disparities for minorities, eliminating health disparities is an overarching priority area for APHA. Community water fluoridation has been shown to be the most cost-effective public health measure for the primary prevention of dental caries and has been shown to be the most effective public health strategy to reduce disparities in dental caries between ethnic and racial groups. Yet, the US public is generally uninformed about the appropriate use of fluoride and community water fluoridation, and information available to the public on community water fluoridation is not always evidence based.
Therefore be it resolved that APHA—
• Reiterates its strong endorsement and recommendation for the fluoridation of all community water systems as a safe and effective public health measure for the prevention of tooth decay;
• Recommends that federal, state, and local agencies and organizations in the United States promote water fluoridation as the foundation for better oral health;
• Recommends promotion and increased support by federal, state, and local entities for adequate public health infrastructure to ensure safe and effective water fluoridation practices, including monitoring, training, technical and financial assistance, and promotion to expand and maintain water fluoridation programs;
• Recommends increased support by federal agencies for continued research on the safety and effectiveness of water fluoridation and other measures to deliver fluoride to communities and individuals, including effective programs and long-term outcomes;
• Supports efforts to educate public health and other health professionals, decisionmakers, and the public on community water fluoridation and other appropriate uses of fluoride in the prevention of tooth decay;
• Recommends that bottled water manufacturers offer an option of bottled water with an optimal level of fluoride, all bottled water be labeled with its fluoride concentration, and APHA collaborate with other professional groups to promote this recommendation;
• Recommends that the FDA consider all US and non-US evidence-based studies concerning low-concentration fluoride toothpaste for children under age 6 during tooth developing years to reduce the risk of enamel fluorosis and tooth decay; and
• Should collaborate with other professional groups to encourage the National Institutes of Health to study the efficacy and safety of low fluoride toothpastes.
1. Newbrun E. The fluoridation war: a scientific dispute or a religious argument? J Public Health Dent. 1996;56(5 Spec No):246–252.
2. Armfield JM. When public action undermines public health: a critical examination of antifluoridationist literature. Aust New Zealand Health Policy. 2007;4(1):25. Available at: www.anzhealthpolicy.com/content/4/1/25. Accessed June 9, 2008.
3. American Dental Association (ADA). Fluoridation Facts. 2005. Question 54. Why does community water fluoridation sometimes lose when it is put to a public vote? Available at: www.ada.org/public/topics/fluoride/facts/fluoridation_facts.pdf. Accessed June 9, 2008.
4. Fluoride Action Network. More communities throw out fluoridation.
December 21, 2006. Available at: www.fluoridealert.org/press/communities.htm. Accessed June 9, 2008.
5. American Public Health Association. APHA Governing Council Resolution 50-05. Fluoridation of public water supplies. Washington, DC: American Public Health Association; 1950.
6. American Public Health Association. APHA Governing Council Resolution 55-08. Fluoridation of public water supplies. Washington, DC: American Public Health Association; 1955.
7. American Public Health Association. APHA Governing Council Resolution 56-07. Commendation for support of fluoridation. Washington, DC: American Public Health Association; 1956.
8. American Public Health Association. APHA Governing Council Resolution 59-04. Adjustment of fluorides in water supplies. Washington, DC: American Public Health Association; 1959.
9. American Public Health Association. APHA Governing Council Resolution 63-13. Dietary fluoride supplement. Washington, DC: American Public Health Association; 1963.
10. American Public Health Association. APHA Governing Council Resolution 65-26(PP). The State public health agency. Washington, DC: American Public Health Association; 1965.
11. American Public Health Association. APHA Governing Council Resolution 69-12. The National Fluoridation Act. Washington, DC: American Public Health Association; 1969.
12. American Public Health Association. APHA Governing Council Resolution 74-02. Fluoridation. Washington, DC: American Public Health Association; 1974.
13. American Public Health Association. APHA Governing Council Resolution 75-20(PP). The establishment of standards of performance for environmental laboratories. Washington, DC: American Public Health Association; 1975.
14. American Public Health Association. APHA Governing Council Resolution 76-33(PP). Policy statement on prevention. Washington, DC: American Public Health Association; 1976.
15. American Public Health Association. APHA Governing Council Resolution 77-11. Dental health in a national health program. Washington, DC: American Public Health Association; 1977.
16. American Public Health Association. APHA Governing Council Resolution 77-21. Development of a national policy of primary prevention. Washington, DC: American Public Health Association; 1977.
17. American Public Health Association. APHA Governing Council Resolution 79-11. Fluoridated communities for the meeting sites of national health organizations. Washington, DC: American Public Health Association; 1979.
18. American Public Health Association. APHA Governing Council Resolution 80-13. Public information role of health officials. Washington, DC: American Public Health Association; 1980.
19. American Public Health Association. APHA Governing Council Resolution 82-01. Engineering safeguards for school fluoridation installations. Washington, DC: American Public Health Association; 1982.
20. American Public Health Association. APHA Governing Council Resolution 82-07. Maintenance of specialty status: dental public health. Washington, DC: American Public Health Association; 1982.
21. American Public Health Association. APHA Governing Council Resolution 92-02. The prevention of diet-related chronic diseases: a national plan for meeting the Year 2000 objectives. Washington, DC: American Public Health Association; 1992.
22. American Public Health Association. APHA Governing Council Resolution 97-06. Evidence-based dental care. Washington, DC: American Public Health Association; 1997.
23. American Public Health Association. APHA Governing Council Resolution 2000-5. Effective interventions for reducing racial and ethnic disparities in health. Washington, DC: American Public Health Association; 2000.
24. American Public Health Association. APHA Governing Council Resolution 2001-17. Support the Framework for Action on Oral Health in America: a report of the surgeon general. Washington, DC: American Public Health Association; 2001.
25. American Public Health Association. APHA Governing Council Resolution 2006-4. Support for the Alaska dental health aide therapist and other innovative programs for underserved populations. Washington, DC: American Public Health Association; 2006.
26. American Dental Association (ADA). Compendium. Available at: www.ada.org/public/topics/fluoride/facts/compendium.asp. Accessed June 9, 2008.
27. Progress Toward Healthy People 2010 Targets. Available at: www.healthypeople.gov/data/midcourse/html/focusareas/FA21ProgressHP.htm. Accessed June 9, 2008.
28. Centers for Disease Control and Prevention (CDC). Populations receiving optimally fluoridated public drinking water—United States, 1992–2006. MMWR Morb Mortal Wkly Rep. 2008 Jul 11;57(27):737–741 Available at: www.cdc.gov/mmwr/preview/mmwrhtml/mm5727a1.htm. Accessed July 13, 2008.
29. British Fluoridation Society. The extent of water fluoridation. In: One in a Million. The Facts About Water Fluoridation. 2nd ed. London, UK: The British Fluoridation Society, The UK Public Health Association, The British Dental Association, and The Faculty of Public Health; 2004: 55–80. Available at: www.bfsweb.org/One%20in%20a%20million/7%20extent.pdf. Accessed on June 9, 2008.
30. Centers for Disease Control and Prevention (CDC). Ten great public health achievements—United States, 1900–1999. MMWR Morb Mortal Wkly Rep. 1999;48(12):241–243. Available at: www.cdc.gov/mmwR/preview/mmwrhtml/00056796.htm. Accessed June 9, 2008.
31. Centers for Disease Control and Prevention (CDC). Advancing the Nation’s Health: A Guide to Public Health Research Needs, 2006–2015. December 2006. Available at: www.cdc.gov/od/science/PHResearch/cdcra/AdvancingTheNationsHealth.pdf. Accessed June 9, 2008.
32. Australian Government. National Health and Medical Research Council. A Systematic Review of the Efficacy and Safety of Fluoridation; 2007. Available at: www.nhmrc.gov.au/publications/synopses/eh41syn.htm. Accessed June 9, 2008.
33. National Research Council (NRC). Health Effects of Ingested Fluoride. Washington, DC: National Academy Press, 1993. Available at: http://www.nap.edu/catalog.php?record_id=2204#toc. Accessed November 18, 2008.
34. National Research Council (NRC). Committee on Fluoride in Drinking Water, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies. Fluoride in Drinking Water: A Scientific Review of EPA’s Standards. Washington, DC; The National Academies Press; 2006. Available at: www.nap.edu/catalog.php?record_id=11571. Accessed June 9, 2008.
35. World Health Organization (WHO). WHO Technical Report Series #846: Report of a WHO Expert Committee on Oral Health Status and Fluoride Use. Geneva, Switzerland: World Health Organization; 1994
36. World Health Organization (WHO). Guidelines for Drinking-Water Quality. 2nd ed. Vol 2. Health criteria and other supporting information. Geneva, Switzerland: WHO; 1996. Available at: www.who.int/water_sanitation_health/dwq/2edvol2p2b.pdf. Accessed June 9, 2008.
37. Fawell J, Bailey K, Chilton J, Dahi E, Fewtrell L, Magara Y. Fluoride in Drinking-water. Geneva, Switzerland: World Health Organization (WHO); 2006. Available at: http://whqlibdoc.who.int/publications/2006/9241563192_eng.pdf. Accessed June 9, 2008.
38. US Agency for Toxic Substances and Disease Registry. Toxicological Profile for Fluorides, Hydrogen Fluoride, and Fluorine. Atlanta, Ga: Agency for Toxic Substances and Disease Registry; 2003. Available at: www.atsdr.cdc.gov/toxprofiles/tp11.pdf. Accessed June 9, 2008.
39. International Programme on Chemical Safety (IPCS). Environmental Health Criteria, No. 227. Fluorides. Geneva, Switzerland: World Health Organization; 2002. Available at: www.inchem.org/documents/ehc/ehc/ehc227.htm. Accessed June 9, 2008.
40. Forum on Water Fluoridation in Ireland 2002. Dublin, Ireland: Government of Ireland; 2002. Available at: www.dohc.ie/publications/fluoridation_forum.html. Accessed June 9, 2008.
41. Medical Research Council. Medical Research Council Working Group Report: Water Fluoridation and Health. September 2002. Available at: www.mrc.ac.uk/Utilities/Documentrecord/index.htm?d=MRC002482. Accessed June 9, 2008.
42. NHS Centre for Reviews and Dissemination, University of York. A Systematic Review of Public Water Fluoridation. York, UK: York Publishing Services Ltd; 2000. Available at: www.york.ac.uk/inst/crd/fluores.htm. Accessed June 9, 2008.
43. McDonagh MS, Whiting PF, Wilson PM, et al. Systematic review of water fluoridation. BMJ. 2000;321(7265):855–859.
44. Institute of Medicine, Food and Nutrition Board. Fluoride: Background Information. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Washington, DC: National Academy Press; 1999. Available at: http://books.nap.edu/openbook.php?isbn=0309063507&page=288. Accessed June 9, 2008.
45. Locker, D. Benefits and Risks of Water Fluoridation. An Update of the 1996 Federal-Provincial Sub-Committee Report. Prepared under contract for the Public Health Branch, Ontario Ministry of Health, First Nations Inuit Health Branch, Health Canada. University of Toronto: Community of Dental Health Services Research Unit, Faculty of Dentistry; 1999. Available at: www.health.gov.on.ca/english/public/pub/ministry_reports/fluoridation/fluor.pdf. Accessed June 9, 2008.
46. Lewis DW, Banting DW. Water fluoridation: current effectiveness and dental fluorosis. Community Dent Oral Epidemiol. 1994;22:153–158.
47. US Public Health Service. Review of Fluoride: Benefits and Risks. Report of the subcommittee on fluoride of the Committee to Coordinate Environmental Health and Related Programs. Washington, DC: Department of Health and Human Services. Public Health Service; 1991. Available at: www.health.gov/environment/ReviewofFluoride/default.htm. Accessed June 9, 2008.
48. Kaminsky LS, Mahoney MC, Leach J, Melius J, Miller MJ. Fluoride: benefits and risks of exposure. Crit Rev Oral Biol Med. 1990;1:261–281 Available at: http://crobm.iadrjournals.org/cgi/reprint/1/4/261. Accessed June 9, 2008.
49. Pollick HF. Water fluoridation and the environment: current perspective in the United States. Int J Occup Environ Health. 2004;10:343–350.
50. Centers for Disease Control and Prevention (CDC). Community Water Fluoridation. Health Effects and Environmental Impact. Available at: www.cdc.gov/fluoridation/safety/health_effects.htm. Accessed June 9, 2008.
51. American Dental Association. Fluoridation Facts. Question 41. What are some of the erroneous health claims made against water fluoridation? 2005. Available at: www.ada.org/public/topics/fluoride/facts/fluoridation_facts.pdf. Accessed June 9, 2008.
52. US Environmental Protection Agency. Drinking Water Contaminants. Available at: www.epa.gov/safewater/contaminants/index.html. Accessed June 9, 2008.
53. Centers for Disease Control and Prevention. Engineering and administrative recommendations for water fluoridation, 1995. MMWR Recomm Rep. 1995;44(RR-13):1–40. Available at: www.cdc.gov/MMWR/preview/mmwrhtml/00039178.htm. Accessed June 9, 2008.
54. NSF Fact Sheet on Fluoridation Chemicals. February 2008. Available at: www.nsf.org/business/water_distribution/pdf/NSF_Fact_Sheet.pdf. Accessed October 26, 2008.
55. Centers for Disease Control and Prevention (CDC). Water Fluoridation Additives, Available at: www.cdc.gov/Fluoridation/fact_sheets/engineering/wfadditives.htm#7. Accessed October 26, 2008.
56. American Dental Association. Fluoridation Facts. 2005. Question 51. Has the legality of water fluoridation been upheld by the courts? Available at: www.ada.org/public/topics/fluoride/facts/fluoridation_facts.pdf. Accessed June 9, 2008.
57. Safe Water Association, Inc., Plaintiff-Appellant, v. City of Fond Du Lac. Court of Appeals of Wisconsin.
184 Wis. 2d 365; 516 N.W.2d 13; 1994 Wisc. App.
LEXIS 529. Available at: www.actionpa.org/fluoride/lawandcourts/wi-fond-du-lac.html. Accessed June 9, 2008.
58. Block LE. Antifluoridationists persist: the constitutional basis for fluoridation. J Public Health Dent. 1986;46(4):188–198.
59. Christoffel T. Fluorides, facts and fanatics: public health advocacy shouldn’t stop at the courthouse door. Am J Public Health. 1985;75:888–891.
60. McMenamin JP. Fluoridation of water in Virginia: the tempest in the teapot. J Law Ethics Dent. 1988;1(1):42–46.
61. Roemer R. Water fluoridation: public health responsibility and the democratic process. Am J Public Health Nations Health. 1965 Sep;55:1337–1348.
62. Strong GA. Liberty, religion, and fluoridation. J Am Dent Assoc. 1968;76(6):1398–1409.
63. Jesus F. Quiles, Appellant, v. The City of Boynton Beach, Florida. Court of Appeal of Florida, Fourth District. 802 So. 2d 397; 2001 Fla. App. LEXIS 16389.
64. Paul Coshow et al., Plaintiffs and Appellants, v. City of Escondido et al., Defendants and Respondents. Court of Appeal of California, Fourth Appellate District, Division One. 132 Cal. App. 4th 687; 34 Cal. Rptr. 3d 19; 2005 Cal. App. LEXIS 1420.
65. City Of Watsonville, Plaintiff and Appellant, v. State Department of Health Services, Defendant and Respondent; California Dental Association, Intervener and Respondent. Court of Appeal of California, Sixth Appellate District. 133 Cal. App. 4th 875; 35 Cal. Rptr. 3d 216; 2005 Cal. App. LEXIS 1664.
66. Pure Water Committee of Western Maryland, Inc., Et Al. V. Mayor and City Council of Cumberland, Maryland, et al. Civil No. JFM-01–2611. United States District Court for the District of Maryland. 2003 U.S. Dist. LEXIS 15830.
67. Dye BA, Tan S, Smith V, et al. Trends in oral health status: United States, 1988–1994 and 1999–2004. Vital Health Stat 11. 2007;No. 248:1–92. Available at: www.cdc.gov/nchs/data/series/sr_11/sr11_248.pdf. Accessed June 9, 2008.
68. Centers for Disease Control and Prevention. Promoting oral health: interventions for preventing dental caries, oral and pharyngeal cancers, and sports-related craniofacial injuries. A report on recommendations of the task force on community preventive services. MMWR Recomm Rep. 2001;50(RR-21):1–13 Available at: www.cdc.gov/mmwr/preview/mmwrhtml/rr5021a1.htm. Accessed June 9, 2008.
69. Griffin SO, Gooch BF, Lockwood SA, Tomar SL. Quantifying the diffused benefit from water fluoridation in the United States. Community Dent Oral Epidemiol.
70. Brunelle JA, Carlos JP.
Recent trends in dental caries in U.S. children and the effect of water fluoridation. J Dent Res. 1990; 69 (special issue):723–727.
71. Newbrun E. Current regulations and recommendations concerning water fluoridation, fluoride supplements, and topical fluoride agents. J Dent Res. 1992;71:1255–1265.
72. Griffin SO, Regnier E, Griffin PM, Huntley V. Effectiveness of fluoride in preventing caries in adults. J Dent Res. 2007;86:410–415.
73. Griffin SO, Griffin PM, Swann JL, Zlobin N. New coronal caries in older adults: implications for prevention. J Dent Res. 2005;84:715–720.
74. Griffin SO, Griffin PM, Swann JL, Zlobin N. Estimating rates of new root caries in older adults.
J Dent Res. 2004;83:634–638.
75. Klein SP, Bohannan HM, Bell RM, Disney JA, Foch CB, Graves RC.
The cost and effectiveness of school-based preventive dental care. Am J Public Health.
76. Griffin SO, Jones K, Tomar SL.
An economic evaluation of community water fluoridation. J Public Health Dent. 2001;61(2):78–86.
77. O’Connell JM, Brunson D, Anselmo T, Sullivan PW.
Costs and savings associated with community water fluoridation programs in Colorado. Prev Chronic Dis [serial online]. 2005 Nov [date cited]. Available at: www.cdc.gov/pcd/issues/2005/nov/05_0082.htm. Accessed June 9, 2008.
78. Centers for Disease Control and Prevention. Recommendations for using fluoride to prevent and control dental caries in the United States. MMWR Recomm Rep. 2001 17;50(RR-14):1–42. Available at: www.cdc.gov/fluoridation/fact_sheets/fl_caries.htm. Accessed June 9, 2008.
79. Centers for Disease Control and Prevention. Cost savings of community water fluoridation. Available at: www.cdc.gov/fluoridation/fact_sheets/cost.htm. Accessed June 9, 2008.
80. Centers for Disease Control and Prevention. Preventing dental caries with community programs. Available at: www.cdc.gov/oralhealth/publications/factsheets/dental_caries.htm. Accessed June 9, 2008.
81. Edelstein BL. The dental caries pandemic and disparities problem. BMC Oral Health. 200615;6(Suppl 1):S2.
82. Jones CM, Taylor GO, Whittle JG, Evans D, Trotter DP. Water fluoridation, tooth decay in 5 year olds, and social deprivation measured by the Jarman score: analysis of data from British dental surveys. BMJ. 1997;315(7107):514–517.
83. Jones C, Taylor G, Woods K, Whittle G, Evans D, Young P. Jarman underprivileged area scores, tooth decay and the effect of water fluoridation. Community Dent Health. 1997;14:156–156.
84. Jones CM, Worthington H. The relationship between water fluoridation and socioeconomic deprivation on tooth decay in 5-year-old children.
Br Dent J. 1999;186:397–400. Erratum in: Br Dent J. 2000;189:390.
85. Jones CM, Worthington H. Water fluoridation, poverty and tooth decay in 12-year-old children. J Dent. 2000;28:389–393.
86. Riley JC, Lennon MA, Ellwood RP. The effect of water fluoridation and social inequalities on dental caries in 5-year-old children. Int J Epidemiol. 1999;28:300–305.
87. Evans DJ, Rugg-Gunn AJ, Tabari ED, Butler T. The effect of fluoridation and social class on caries experience in 5-year-old Newcastle children in 1994 compared with results over the previous 18 years. Community Dent Health. 1996;13(1):5–10.
88. Burt BA. Fluoridation and social equity. J Public Health Dent. 2002;62(4):195–220.
89. Centers for Disease Control and Prevention. Community Water Fluoridation. Benefits. Available at: www.cdc.gov/fluoridation/benefits.htm. Accessed June 9, 2008.
90. Larson RH, Mellberg JR, Senning R. Experiments on local and systemic action of fluoride in caries inhibition in the rat. Arch Oral Biol. 1977;22:437–439.
91. Groeneveld A, Van Eck AA, Backer Dirks O. Fluoride in caries prevention: is the effect pre- or post-eruptive? J Dent Res. 1990;69 (special issue):751–755; discussion 820–823.
92. Singh KA, Spencer AJ, Brennan DS.
Effects of water fluoride exposure at crown completion and maturation on caries of permanent first molars. Caries Res. 2007;41(1):34–42.
93. Singh KA, Spencer AJ. Relative effects of pre- and post-eruption water fluoride on caries experience by surface type of permanent first molars. Community Dent Oral Epidemiol. 2004;32:435–446.
94. Singh KA, Spencer AJ, Armfield JM. Relative effects of pre- and posteruption water fluoride on caries experience of permanent first molars. J Public Health Dent. 2003;63(1):11–19.
95. National Research Council (NRC). Committee on Fluoride in Drinking Water, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies. Fluoride in Drinking Water: A Scientific Review of EPA’s Standards. Washington, DC: The National Academies Press; 2006. Available at: www.nap.edu/catalog.php?record_id=11571. Accessed June 9, 2008.
96. Pendrys DG. Risk of enamel fluorosis in nonfluoridated and optimally fluoridated populations: considerations for the dental professional. J Am Dent Assoc. 2000;131:746–755.
97. Beltrán-Aguilar ED, Barker LK, Canto MT, et al. Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis—United States, 1988–1994 and 1999–2002. MMWR Surveill Summ. 2005;54(3):1–43. Available at: www.cdc.gov/mmwr/preview/mmwrhtml/ss5403a1.htm. Accessed June 9, 2008.
98. Griffin SO, Beltrán ED, Lockwood SA, Barker LK. Esthetically objectionable fluorosis attributable to water fluoridation. Community Dent Oral Epidemiol. 2002;30:199–209.
99. Do LG, Spencer A. Oral health-related quality of life of children by dental caries and fluorosis experience. J Public Health Dent. 2007;67(3):132–139.
100. Osuji OO, Leake JL, Chipman ML, Nikiforuk G, Locker D, Levine N. Risk factors for dental fluorosis in a fluoridated community. J Dent Res. 1988;67(12):1488–1492.
101. Do LG, Spencer AJ. Risk-benefit balance in the use of fluoride among young children. J Dent Res. 2007;86:723–728.
102. US Department of Agriculture. USDA National Fluoride Database of Selected Beverages and Foods. Beltsville, Md: Agricultural Research Service. Beltsville Human Nutrition Research Center. Nutrient Data Laboratory; 2004. Available at: www.nal.usda.gov/fnic/foodcomp/Data/Fluoride/fluoride.pdf. Accessed June 9, 2008.
103. American Dental Association. Fluoridation Facts. 2005. Table 3: Dietary Reference Intakes for Fluoride; Page 25. Available at: www.ada.org/public/topics/fluoride/facts/fluoridation_facts.pdf. Accessed June 9, 2008.
104. US Environmental Protection Agency (USEPA). Sulfuryl Fluoride; Pesticide Tolerance. 40 CFR Part 180. [OPP-2003-0373; FRL-7342-1]. Available at: www.epa.gov/fedrgstr/EPA-PEST/2004/January/Day-23/p1540.htm. Accessed June 9, 2008.
105. American Dental Association (ADA). Fluoride and Infant Formula Frequently Asked Questions (FAQ). Available at: www.ada.org/public/topics/fluoride/infantsformula_faq.asp. Accessed November 19, 2008.
106. Centers for Disease Control and Prevention (CDC). Background: Infant Formula and the Risk for Enamel Fluorosis. Available at: www.cdc.gov/fluoridation/safety/infant_formula.htm. Accessed June 9, 2008.
107. Pendrys DG. Risk for fluorosis in a fluoridated population: implications for the dentist and hygienist. J Am Dent Assoc. 1995;126:1617–1624.
108. US Food and Drug Administration (FDA). Anticaries drug products for over-the-counter human use. 21 CFR Part 355. Code of Federal Regulations 1999:280–285.
109. Winter GB, Holt RD, Williams BF. Clinical trial of a low-fluoride toothpaste for young children. Int Dent J. 1989;39:227–235.
110. Holt RD, Morris CE, Winter GB, Downer MC. Enamel opacities and dental caries in children who used a low fluoride toothpaste between 2 and 5 years of age.
Int Dent J. 1994;44:331–341.
111. Riordan PJ.
Dental fluorosis decline after changes to supplement and toothpaste regimens. Community Dent Oral Epidemiol. 2002;30:233–240.
112. Armfield JM, Spencer AJ. Community effectiveness of fissure sealants and the effect of fluoridated water consumption. Community Dent Health. 2007;24(1):4–11.
113. Food and Drug Administration (FDA). Center for Food Safety and Applied Nutrition. Health Claim Notification for Fluoridated Water and Reduced Risk of Dental Caries. Available at: www.cfsan.fda.gov/~dms/flfluoro.html. Accessed June 9, 2008.
114. Broffitt B, Levy SM, Warren JJ, Cavanaugh JE. An investigation of bottled water use and caries in the mixed dentition. J Public Health Dent. 2007;67:151–158.
115. Armfield JM, Spencer AJ. Consumption of nonpublic water: implications for children’s caries experience. Community Dent Oral Epidemiol. 2004;32:283–296.
116. American Dental Association (ADA). New ADA program tags Smile Healthy products. Posted Jan. 23, 2008. Available at: www.ada.org/prof/resources/pubs/adanews/adanewsarticle.asp?articleid=2851. Accessed June 9, 2008.
117. International Bottled Water Association. Statistics and water quality. Beverage Marketing’s 2007 Market Report Findings. Available at: www.bottledwater.org/public/statistics_main.htm. Accessed June 9, 2008.
118. US Environmental Protection Agency. Estimated per Capita Water Ingestion and Body Weight in the United States—An Update. Washington, DC: US Environmental Protection Agency, Office of Water, Office of Science and Technology. EPA-822-R-00-001. October 2004. Available at: www.epa.gov/waterscience/criteria/drinking/percapita/2004.pdf. Accessed June 9, 2008.
119. American Dental Association. ADA Policy on Bottled Water, Home Water Treatment Systems and Fluoride Exposure. 2002. Available at: www.ada.org/prof/resources/positions/statements/bottledwater.asp. Accessed June 9, 2008.
120. Petersen PE. The World Oral Health report 2003: continuous improvement of oral health in the 21st century—the approach of the WHO Global Oral Health Programme. Community Dent Oral Epidemiol 2003;31(Suppl 1):3–24.
121. Horowitz HS. Decision-making for national programs of community fluoride use. Community Dent Oral Epidemiol. 2000;28:321–329.
122. Horowitz HS. The role of dietary fluoride supplements in caries prevention. J Public Health Dent. 1999;59:205–210.
123. American Dental Association. Fluoride Supplement Dosage Schedule—1994. Available at: www.ada.org/public/topics/fluoride/fluoride_article01.asp#dosage. Accessed June 9, 2008.
124. Levy SM, Muchow G. Provider compliance with recommended dietary fluoride supplement protocol. Am J Public Health. 1992;82:281–283.
125. Osso D, Tinanoff N, Romberg E, Syme S, Roberts M. Relationship of naturally occurring fluoride in Carroll County, Maryland, to aquifers, well depths, and fluoride supplementation prescribing behaviors.
J Dent Hyg. 2008;82(1):10.
126. Levy SM, Kiritsy MC, Slager SL, Warren JJ., Patterns of dietary fluoride supplements use during infancy. J Public Health Dent. 1998;158:228–233.
127. Newbrun E. Water fluoridation and fluoridation supplements in caries prevention. J Calif Dent Assoc. 1980;838–847.
128. Newbrun E. The case for reducing the current Council on Dental Therapeutics fluoride supplementation schedule. J Public Health Dent. 1999;59:263–268.
129. Newbrun E. Fluorides and Dental Caries. 3rd ed. Springfield, Ill: Charles C. Thomas; 1986:143.
130. Association of State and Territorial Dental Directors. Fluorides Committee. Fluoride Varnish: An Evidence-Based Approach Research Brief. September 2007. Available at: www.astdd.org/docs/FluorideVarnishPaperASTDDSept2007.pdf. Accessed June 9, 2008.
131. American Dental Association (ADA). Fluoridation Facts. 2005. Question 52. Why does opposition to community water fluoridation continue? Available at: www.ada.org/public/topics/fluoride/facts/fluoridation_facts.pdf. Accessed June 9, 2008.
132. Centers for Disease Control and Prevention (CDC). Community Water Fluoridation. Available at: www.cdc.gov/fluoridation/. Accessed June 9, 2008.
133. American Dental Association (ADA). Fluoride and Fluoridation. Available at: www.ada.org/public/topics/fluoride/index.asp. Accessed June 9, 2008.
134. American Dental Association (ADA). Fluoridation Facts. 2005. Available at: www.ada.org/public/topics/fluoride/facts/fluoridation_facts.pdf. Accessed June 9, 2008.
135. American Dental Association (ADA). Community water fluoridation resources. Available at: www.ada.org/prof/resources/topics/topics_fluoridation_resources.pdf. Accessed June 9, 2008.
136. Kim C, Yamamoto LG.
Water fluoridation information found on the World Wide Web.
Hawaii Med J. 2004;63(6):185–186.
137. McNally M, Downie J. The ethics of water fluoridation. J Can Dent Assoc. 2000;66:592–593.
138. Nuffield Council on Bioethics. Public Health: Ethical Issues. 2007. Available at: www.nuffieldbioethics.org. Accessed June 9, 2008.
139. British Fluoridation Society. One in a Million—the Facts About Water Fluoridation. 2nd ed. Chapter 10. The ethics of water fluoridation. Available at: www.bfsweb.org/onemillion/onemillion.htm. Accessed June 9, 2008.
140. Mendoza VC. The ethical dilemma of water fluoridation.
Rev Med Chil. 2007;135:1487–1493.
Epub 2008 Jan 16. Translation available at: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001100018&lng=es&nrm=iso. Accessed on December 7, 2008